Department of Medicine, Duke University School of Medicine, Durham, NC. Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC. Center for Genomic and Computational Biology, Duke University School of Medicine, Durham, NC; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC. Department of Medicine, Duke University School of Medicine, Durham, NC; Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC. Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC. Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA. Litholink Corp, Laboratory Corporation of America Holdings, Chicago, IL. Department of Medicine, Duke University School of Medicine, Durham, NC; Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC. Department of Medicine, Duke University School of Medicine, Durham, NC; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC. Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA. Electronic address: jscialla@virginia.edu.